Version 5.4
Homo sapiens Gene: EGFL7
Summary
InnateDB Gene IDBG-92509.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EGFL7
Gene Name EGF-like-domain, multiple 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172889
Encoded Proteins
IDBP-92511
EGF-like-domain, multiple 7
IDBP-92513
EGF-like-domain, multiple 7
IDBP-92515
EGF-like-domain, multiple 7
IDBP-294005
EGF-like-domain, multiple 7
IDBP-809669
EGF-like-domain, multiple 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:136658856-136672678
Strand Forward strand
Band q34.3
Transcripts
ENST00000371699 ENSP00000360764
ENST00000308874 ENSP00000307843
ENST00000371698 ENSP00000360763
ENST00000406555 ENSP00000385639
ENST00000492862 ENSP00000473338
ENST00000490469
ENST00000492002
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005112 Notch binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0007155 cell adhesion
GO:0030336 negative regulation of cell migration
GO:0045746 negative regulation of Notch signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000026921
View Gene Order
Cross-References
SwissProt Q9UHF1
TrEMBL A0A024R8F5 R4GMT3
UniProt Splice Variant
Entrez Gene 51162
UniGene Hs.736185 Hs.91481
RefSeq NM_016215 NM_201446
HUGO HGNC:20594
OMIM 608582
CCDS CCDS7002
HPRD 16351
IMGT
EMBL AB125649 AF186111 AK091964 AL512735 AL590226 AY358901 AY358902 AY358903 BC012377 BC088371 CH471090 KC485578
GenPept AAF01429 AAH12377 AAH88371 AAQ89260 AAQ89261 AAQ89262 AGJ83826 BAD01469 BAG52452 CAC21666 CAH71721 EAW88247 EAW88248
RNA Seq Atlas 51162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca