Version 5.4
| Homo sapiens Protein: CD109 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-92572.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | CD109 | ||||||||
| Protein Name | CD109 molecule | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000287097 | ||||||||
| InnateDB Gene | IDBG-92570 (CD109) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Modulates negatively TGFB1 signaling in keratinocytes. {ECO:0000269PubMed:16754747}. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000269PubMed:11861284, ECO:0000269PubMed:16754747}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:11861284, ECO:0000269PubMed:16754747}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta. {ECO:0000269PubMed:11861284, ECO:0000269PubMed:14980714, ECO:0000269PubMed:16754747}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR001599
Alpha-2-macroglobulin IPR002890 Alpha-2-macroglobulin, N-terminal IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid IPR009048 Alpha-macroglobulin, receptor-binding IPR011625 Alpha-2-macroglobulin, N-terminal 2 IPR011626 Alpha-macroglobulin complement component IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming |
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| PFAM |
PF00207
PF01835 PF07677 PF07703 PF07678 PF10569 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q6YHK3 | ||||||||
| PhosphoSite | PhosphoSite-Q6YHK3 | ||||||||
| TrEMBL | Q5XUN1 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 135228 | ||||||||
| UniGene | Hs.602024 | ||||||||
| RefSeq | NP_598000 | ||||||||
| HUGO | HGNC:21685 | ||||||||
| OMIM | 608859 | ||||||||
| CCDS | CCDS4982 | ||||||||
| HPRD | 10590 | ||||||||
| IMGT | |||||||||
| EMBL | AF410459 AF410460 AK095888 AK123960 AK313636 AL590428 AL591480 AL834478 AY149920 AY736553 AY736555 AY736556 AY736557 AY736558 AY788891 BX641095 EF553520 HQ202739 | ||||||||
| GenPept | AAL84159 AAL84160 AAN78483 AAU94640 AAU94642 AAU94643 AAU94644 AAU94645 AAX14639 ABQ66266 ADZ28543 BAC04642 BAG36395 BAG53987 CAD39137 CAE46045 CAI15636 | ||||||||