Homo sapiens Gene: CD109
Summary
InnateDB Gene IDBG-92570.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD109
Gene Name CD109 molecule
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000156535
Encoded Proteins
CD109 molecule
CD109 molecule
CD109 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:73695785-73828316
Strand Forward strand
Band q13
Transcripts
ENST00000287097 ENSP00000287097
ENST00000422508 ENSP00000404475
ENST00000437994 ENSP00000388062
ENST00000474094
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061045 negative regulation of wound healing
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.399891 Hs.600032 Hs.602024
RefSeq NM_001159587 NM_001159588 NM_133493 XM_005248659
HUGO
OMIM
CCDS CCDS4982 CCDS55038 CCDS55039
HPRD 10590
IMGT
EMBL
GenPept
RNA Seq Atlas