InnateDB Protein
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IDBP-92619.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CAPZB
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Protein Name
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capping protein (actin filament) muscle Z-line, beta
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Synonyms
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CAPB; CAPPB; CAPZ;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000264202
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InnateDB Gene
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IDBG-92609 (CAPZB)
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Protein Structure
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Function |
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269PubMed:21834987}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
51
[view]
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Protein-Protein |
51
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001698
F-actin-capping protein subunit beta
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PFAM |
PF01115
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PRINTS |
PR00192
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P47756
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PhosphoSite |
PhosphoSite-P47756
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TrEMBL |
Q7L4N0
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UniProt Splice Variant |
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Entrez Gene |
832
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UniGene |
Hs.432760
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RefSeq |
NP_004921
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HUGO |
HGNC:1491
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OMIM |
601572
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CCDS |
CCDS41277
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HPRD |
11872
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IMGT |
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EMBL |
AL035413
AL359199
AL445163
BC008095
BC024601
BC107752
BC109241
BC109242
BT019470
BT019471
CH471134
U03271
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GenPept |
AAA87395
AAH08095
AAH24601
AAI07753
AAI09242
AAI09243
AAV38277
AAV38278
CAH71392
CAH72124
CAI22231
EAW94888
EAW94890
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