InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G2E

Summary

InnateDB Protein

IDBP-92783.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G2E

Protein Name

phospholipase A2, group IIE

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364257

InnateDB Gene

IDBG-92781 (PLA2G2E)

Protein Structure

UniProt Annotation

Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Restricted to the brain, heart, lung, and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004623	phospholipase A2 activity
GO:0005509	calcium ion binding

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006954	inflammatory response
GO:0016042	lipid catabolic process
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036149	phosphatidylinositol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process