InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDA

Summary

InnateDB Protein

IDBP-92907.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDA

Protein Name

cytidine deaminase

Synonyms

CDD;

Species

Homo sapiens

Ensembl Protein

ENSP00000364212

InnateDB Gene

IDBG-92905 (CDA)

Protein Structure

UniProt Annotation

Function

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001882	nucleoside binding
GO:0003824	catalytic activity
GO:0004126	cytidine deaminase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006206	pyrimidine nucleobase metabolic process
GO:0007166	cell surface receptor signaling pathway
GO:0008655	pyrimidine-containing compound salvage
GO:0009972	cytidine deamination
GO:0019858	cytosine metabolic process
GO:0030308	negative regulation of cell growth
GO:0043097	pyrimidine nucleoside salvage
GO:0044281	small molecule metabolic process
GO:0045980	negative regulation of nucleotide metabolic process
GO:0051289	protein homotetramerization
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR002125 CMP/dCMP deaminase, zinc-binding
IPR006262 Cytidine deaminase, homotetrameric
IPR013171 Cytidine/deoxycytidylate deaminase, zinc-binding domain
IPR016193 Cytidine deaminase-like

PFAM

PF00383
PF08211

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32320

PhosphoSite