InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCA2

Summary

InnateDB Protein

IDBP-92981.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCA2

Protein Name

ATP-binding cassette, sub-family A (ABC1), member 2

Synonyms

ABC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000360666

InnateDB Gene

IDBG-92973 (ABCA2)

Protein Structure

UniProt Annotation

Function

Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.

Subcellular Localization

Endosome membrane {ECO:0000269PubMed:11309290}; Multi-pass membrane protein {ECO:0000269PubMed:11309290}. Lysosome membrane {ECO:0000269PubMed:11309290}; Multi-pass membrane protein {ECO:0000269PubMed:11309290}. Note=Forms discrete, punctate intracellular vesicles.

Disease Associations

Tissue Specificity

Highly expressed in the brain, whereas lower levels of expression is observed in kidney and liver. {ECO:0000269PubMed:11309290}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006629	lipid metabolic process
GO:0006810	transport
GO:0032383	regulation of intracellular cholesterol transport
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0048545	response to steroid hormone
GO:0055085	transmembrane transport

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005815	microtubule organizing center
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0043190	ATP-binding cassette (ABC) transporter complex