InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PMM1

Summary

InnateDB Protein

IDBP-9303.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PMM1

Protein Name

phosphomannomutase 1

Synonyms

Sec53;

Species

Homo sapiens

Ensembl Protein

ENSP00000216259

InnateDB Gene

IDBG-9301 (PMM1)

Protein Structure

UniProt Annotation

Function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269PubMed:16540464}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004615	phosphomannomutase activity
GO:0046872	metal ion binding

Biological Process

GO:0006013	mannose metabolic process
GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0008152	metabolic process
GO:0009298	GDP-mannose biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019307	mannose biosynthetic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process