Version 5.4
Homo sapiens Gene: PMM1
Summary
InnateDB Gene IDBG-9301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PMM1
Gene Name phosphomannomutase 1
Synonyms Sec53
Species Homo sapiens
Ensembl Gene ENSG00000100417
Encoded Proteins
IDBP-9303
phosphomannomutase 1
IDBP-378140
phosphomannomutase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:41576894-41589890
Strand Reverse strand
Band q13.2
Transcripts
ENST00000216259 ENSP00000216259
ENST00000414636 ENSP00000400889
ENST00000463617
ENST00000482178
ENST00000472620
ENST00000485648
ENST00000466645
ENST00000478337
ENST00000493389
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004615 phosphomannomutase activity
GO:0046872 metal ion binding
Biological Process
GO:0006013 mannose metabolic process
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0008152 metabolic process
GO:0009298 GDP-mannose biosynthetic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019307 mannose biosynthetic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022474
View Gene Order
ENSBTAG00000004009
Not yet available
Pathways
NETPATH
REACTOME
REACT_22423
Synthesis of GDP-mannose pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.642234
RefSeq NM_002676
HUGO
OMIM
CCDS CCDS14020
HPRD 03473
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca