InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DOCK1

Summary

InnateDB Protein

IDBP-93120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOCK1

Protein Name

dedicator of cytokinesis 1

Synonyms

ced5; DOCK180;

Species

Homo sapiens

Ensembl Protein

ENSP00000280333

InnateDB Gene

IDBG-93118 (DOCK1)

Protein Structure

UniProt Annotation

Function

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. {ECO:0000269PubMed:8657152}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}. Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005488	binding
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0017124	SH3 domain binding
GO:0020037	heme binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006911	phagocytosis, engulfment
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007229	integrin-mediated signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0016477	cell migration
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043547	positive regulation of GTPase activity
GO:0045087	innate immune response

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR009056 Cytochrome c-like domain
IPR010703 Dedicator of cytokinesis C-terminal
IPR011511 Variant SH3 domain
IPR016024 Armadillo-type fold

PFAM

PF00018
PF14604
PF13442
PF06920
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt