InnateDB Protein
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IDBP-93135.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SENP6
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Protein Name
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SUMO1/sentrin specific peptidase 6
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Synonyms
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SSP1; SUSP1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000359027
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InnateDB Gene
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IDBG-93129 (SENP6)
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Protein Structure
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Function |
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269PubMed:16912044, ECO:0000269PubMed:17000875, ECO:0000269PubMed:18799455, ECO:0000269PubMed:20212317, ECO:0000269PubMed:20705237, ECO:0000269PubMed:21148299}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:16912044, ECO:0000269PubMed:17000875}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in reproductive organs, such as testis, ovary and prostate.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003653
Peptidase C48, SUMO/Sentrin/Ubl1
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PFAM |
PF02902
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9GZR1
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PhosphoSite |
PhosphoSite-Q9GZR1
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TrEMBL |
F8W6D9
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UniProt Splice Variant |
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Entrez Gene |
26054
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UniGene |
Hs.627115
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RefSeq |
NP_001093879
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HUGO |
HGNC:20944
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OMIM |
605003
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CCDS |
CCDS43483
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HPRD |
05417
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IMGT |
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EMBL |
AB018340
AF196304
AF306508
AF307849
AK096455
AL109897
AL355797
AL356057
AL589656
BC028583
CH471051
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GenPept |
AAF04852
AAG29831
AAG30253
AAH28583
BAA34517
BAC04794
CAH72480
CAH72481
CAH74168
CAH74170
CAI19523
CAI23575
CAI23576
EAW48734
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