Homo sapiens Protein: PTPRE | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-93145.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PTPRE | ||||||||||||||||||||||
Protein Name | protein tyrosine phosphatase, receptor type, E | ||||||||||||||||||||||
Synonyms | HPTPE; PTPE; R-PTP-EPSILON; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000303350 | ||||||||||||||||||||||
InnateDB Gene | IDBG-93141 (PTPRE) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). {ECO:0000250}.Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin- induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity). {ECO:0000250}.Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity). {ECO:0000250}.Isoform 3: Cytoplasm. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells). {ECO:0000269PubMed:8610169}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000242
Protein-tyrosine phosphatase, receptor/non-receptor type IPR000387 Protein-tyrosine/Dual specificity phosphatase IPR003595 Protein-tyrosine phosphatase, catalytic IPR016336 Receptor tyrosine-protein phosphatase, alpha/epsilon-type IPR029021 Protein-tyrosine phosphatase-like |
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PFAM |
PF00102
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PRINTS |
PR00700
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PIRSF |
PIRSF002006
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SMART |
SM00194
SM00404 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P23469 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P23469 | ||||||||||||||||||||||
TrEMBL | Q69YS2 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 5791 | ||||||||||||||||||||||
UniGene | Hs.127022 | ||||||||||||||||||||||
RefSeq | NP_569119 | ||||||||||||||||||||||
HUGO | HGNC:9669 | ||||||||||||||||||||||
OMIM | 600926 | ||||||||||||||||||||||
CCDS | CCDS7658 | ||||||||||||||||||||||
HPRD | 02956 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AJ315969 AK291828 AL390236 AL832042 BC050062 CH471066 U36623 X54134 | ||||||||||||||||||||||
GenPept | AAC50324 AAH50062 BAF84517 CAA38069 CAC86583 CAH10411 CAH73173 CAH73174 EAW49180 EAW49181 EAW49182 EAW49184 | ||||||||||||||||||||||