InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUBP2

Summary

InnateDB Protein

IDBP-9322.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUBP2

Protein Name

nucleotide binding protein 2

Synonyms

CFD1; NBP 2; NUBP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000262302

InnateDB Gene

IDBG-9320 (NUBP2)

Protein Structure

UniProt Annotation

Function

Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. {ECO:0000255HAMAP-Rule:MF_03039}.

Subcellular Localization

Nucleus {ECO:0000255HAMAP-Rule:MF_03039}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255HAMAP-Rule:MF_03039}. Note=Enriched at the centrosomes during mitosis. {ECO:0000255HAMAP-Rule:MF_03039}.

Disease Associations

Tissue Specificity

Widely expressed with highest expression in skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0016226	iron-sulfur cluster assembly
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031616	spindle pole centrosome

Protein Structure and Domains

PDB ID

InterPro

IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain
IPR005129 ArgK protein
IPR015223 ATPase MipZ/NubP2/Cfd1
IPR019591 Mrp/NBP35 ATP-binding protein
IPR025723 Anion-transporting ATPase-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01656
PF03308
PF09140
PF10609
PF02374

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y5Y2

PhosphoSite