InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NDOR1

Summary

InnateDB Protein

IDBP-93231.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDOR1

Protein Name

NADPH dependent diflavin oxidoreductase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000343344

InnateDB Gene

IDBG-93227 (NDOR1)

Protein Structure

UniProt Annotation

Function

Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. {ECO:0000255HAMAP-Rule:MF_03178, ECO:0000269PubMed:10625700, ECO:0000269PubMed:20802492, ECO:0000269PubMed:23596212}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000255HAMAP-Rule:MF_03178, ECO:0000269PubMed:10625700, ECO:0000269PubMed:12871939}. Note=Concentrated in perinuclear structure.

Disease Associations

Tissue Specificity

Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitt's lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361. {ECO:0000269PubMed:12871939}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003958	NADPH-hemoprotein reductase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0008219	cell death
GO:0016226	iron-sulfur cluster assembly
GO:0036245	cellular response to menadione
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0045111	intermediate filament cytoskeleton
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001094 Flavodoxin
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR003097 FAD-binding, type 1
IPR008254 Flavodoxin/nitric oxide synthase
IPR017938 Riboflavin synthase-like beta-barrel
IPR029039 Flavoprotein-like

PFAM

PF00175
PF00667
PF00258

PRINTS

PR00369
PR00371

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UHB4