Version 5.4
Homo sapiens Gene: NDOR1
Summary
InnateDB Gene IDBG-93227.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDOR1
Gene Name NADPH dependent diflavin oxidoreductase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188566
Encoded Proteins
IDBP-93229
NADPH dependent diflavin oxidoreductase 1
IDBP-93231
NADPH dependent diflavin oxidoreductase 1
IDBP-384487
NADPH dependent diflavin oxidoreductase 1
IDBP-384488
NADPH dependent diflavin oxidoreductase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:137205670-137217009
Strand Forward strand
Band q34.3
Transcripts
ENST00000371521 ENSP00000360576
ENST00000344894 ENSP00000343344
ENST00000427047 ENSP00000394309
ENST00000458322 ENSP00000389905
ENST00000613750
ENST00000612145
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003958 NADPH-hemoprotein reductase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0008219 cell death
GO:0016226 iron-sulfur cluster assembly
GO:0036245 cellular response to menadione
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0045111 intermediate filament cytoskeleton
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006471
View Gene Order
ENSBTAG00000047061
Not yet available
Pathways
NETPATH
REACTOME
REACT_160176
Cytosolic iron-sulfur cluster assembly pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9UHB4
TrEMBL
UniProt Splice Variant
Entrez Gene 27158
UniGene
RefSeq NM_001144027 NM_001144026 NM_001144028 NM_014434
HUGO HGNC:29838
OMIM 606073
CCDS CCDS48063 CCDS48061 CCDS48062 CCDS7036
HPRD 10444
IMGT
EMBL AF199509 AK074403 AK290026 AL929554 AY077845 BC015735 BC093782 BC111943 BX255925
GenPept AAF25205 AAH15735 AAH93782 AAI11944 AAL77754 BAF82715 CAH72886 CAM24151
RNA Seq Atlas 27158

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca