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InnateDB Protein
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IDBP-93400.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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USP48
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Protein Name
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ubiquitin specific peptidase 48
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000363864
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InnateDB Gene
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IDBG-93396 (USP48)
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Protein Structure
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| Function |
Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. {ECO:0000269PubMed:16214042}.
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| Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16214042}. Nucleus {ECO:0000269PubMed:16214042}.
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| Disease Associations |
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| Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:14715245, ECO:0000269PubMed:15354349, ECO:0000269PubMed:16214042}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
16
[view]
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| Protein-Protein |
16
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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Molecular Function |
| Accession |
GO Term |
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GO:0004843
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ubiquitin-specific protease activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR006615
Peptidase C19, ubiquitin-specific peptidase, DUSP domain
IPR029071
Ubiquitin-related domain
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| PFAM |
PF06337
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| PRINTS |
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| PIRSF |
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| SMART |
SM00695
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q86UV5
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
84196
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| UniGene |
Hs.467524
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| RefSeq |
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| HUGO |
HGNC:18533
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| OMIM |
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| CCDS |
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| HPRD |
15637
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4