Version 5.4
Homo sapiens Gene: USP48
Summary
InnateDB Gene IDBG-93396.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP48
Gene Name ubiquitin specific peptidase 48
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000090686
Encoded Proteins
IDBP-93398
ubiquitin specific peptidase 48
IDBP-93400
ubiquitin specific peptidase 48
IDBP-93402
ubiquitin specific peptidase 48
IDBP-228521
ubiquitin specific peptidase 48
IDBP-374341
ubiquitin specific peptidase 48
IDBP-590554
ubiquitin specific peptidase 48
IDBP-593722
ubiquitin specific peptidase 48
IDBP-590055
ubiquitin specific peptidase 48
IDBP-583891
ubiquitin specific peptidase 48
IDBP-600731
ubiquitin specific peptidase 48
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:21678298-21783606
Strand Reverse strand
Band p36.12
Transcripts
ENST00000308271 ENSP00000309262
ENST00000374732 ENSP00000363864
ENST00000374730 ENSP00000363862
ENST00000400301 ENSP00000383157
ENST00000421625 ENSP00000406256
ENST00000487880
ENST00000479177
ENST00000464577
ENST00000471752
ENST00000489108
ENST00000529637 ENSP00000431949
ENST00000526044 ENSP00000431832
ENST00000534705 ENSP00000435604
ENST00000527823 ENSP00000434073
ENST00000532737 ENSP00000435612
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000043411
View Gene Order
ENSBTAG00000006940
Not yet available
Cross-References
SwissProt Q86UV5
TrEMBL E9PJ87 E9PRY5
UniProt Splice Variant
Entrez Gene 84196
UniGene Hs.467524
RefSeq NM_001032730 NM_032236 XM_005246009 XM_005246010 XM_006710949 XM_006710950 XM_006710951 XM_006710952 XM_006710954 XM_006710956
HUGO HGNC:18533
OMIM
CCDS CCDS44084 CCDS30623
HPRD 15637
IMGT
EMBL AF502942 AK000110 AK002190 AK026707 AK026930 AL359815 AL590103 AL834375 BC007326 BC013567 BC067261 BC103724 BC104896 BC143354
GenPept AAH07326 AAH13567 AAH67261 AAI03725 AAI04897 AAI43355 AAP30832 BAA90950 BAA92128 BAB15533 BAB15591 CAD39038 CAI12124 CAI12127 CAI16256 CAI16260
RNA Seq Atlas 84196

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca