Version 5.4
Homo sapiens Protein: HMGN3
Summary
InnateDB Protein IDBP-93405.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGN3
Protein Name high mobility group nucleosomal binding domain 3
Synonyms PNAS-25; TRIP7;
Species Homo sapiens
Ensembl Protein ENSP00000341267
InnateDB Gene IDBG-93403 (HMGN3)
Protein Structure
UniProt Annotation
Function Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries. {ECO:0000269PubMed:11356838, ECO:0000269PubMed:7776974}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0031492 nucleosomal DNA binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0008150 biological_process
GO:0016568 chromatin modification
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000079 High mobility group nucleosome-binding domain-containing family
PFAM PF01101
PRINTS PR00925
PIRSF
SMART SM00527
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15651
PhosphoSite PhosphoSite-Q15651
TrEMBL
UniProt Splice Variant
Entrez Gene 9324
UniGene
RefSeq NP_004233
HUGO HGNC:12312
OMIM 604502
CCDS CCDS4988
HPRD 16062
IMGT
EMBL AF274949 AF401520 AK315391 AL355796 AY043282 BC009529 BK000003 BK000006 BX648085 CH471051 L40357
GenPept AAA73877 AAH09529 AAK07526 AAK85736 AAK92012 BAG37784 CAH74094 CAH74095 CAI46267 DAA00392 DAA00395 EAW48711

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca