Version 5.4
Homo sapiens Gene: HMGN3
Summary
InnateDB Gene IDBG-93403.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGN3
Gene Name high mobility group nucleosomal binding domain 3
Synonyms PNAS-25; TRIP7
Species Homo sapiens
Ensembl Gene ENSG00000118418
Encoded Proteins
IDBP-93405
high mobility group nucleosomal binding domain 3
IDBP-93407
high mobility group nucleosomal binding domain 3
IDBP-810819
high mobility group nucleosomal binding domain 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:79201245-79234738
Strand Reverse strand
Band q14.1
Transcripts
ENST00000344726 ENSP00000341267
ENST00000275036 ENSP00000275036
ENST00000620514 ENSP00000482613
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0031492 nucleosomal DNA binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008150 biological_process
GO:0016568 chromatin modification
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000066456
View Gene Order
ENSBTAG00000001422
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001201362 NM_001201363 NM_004242 NM_138730 XM_005248768 XM_005248769
HUGO
OMIM
CCDS CCDS4988 CCDS4989 CCDS75485
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca