InnateDB Protein
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IDBP-93407.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HMGN3
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Protein Name
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high mobility group nucleosomal binding domain 3
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Synonyms
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PNAS-25; TRIP7;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000275036
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InnateDB Gene
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IDBG-93403 (HMGN3)
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Protein Structure
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Function |
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries. {ECO:0000269PubMed:11356838, ECO:0000269PubMed:7776974}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000079
High mobility group nucleosome-binding domain-containing family
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PFAM |
PF01101
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PRINTS |
PR00925
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PIRSF |
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SMART |
SM00527
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TIGRFAMs |
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Modification |
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SwissProt |
Q15651
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PhosphoSite |
PhosphoSite-Q15651
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9324
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UniGene |
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RefSeq |
NP_620058
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HUGO |
HGNC:12312
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OMIM |
604502
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CCDS |
CCDS4989
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HPRD |
16062
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IMGT |
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EMBL |
AF274949
AF401520
AK315391
AL355796
AY043282
BC009529
BK000003
BK000006
BX648085
CH471051
L40357
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GenPept |
AAA73877
AAH09529
AAK07526
AAK85736
AAK92012
BAG37784
CAH74094
CAH74095
CAI46267
DAA00392
DAA00395
EAW48711
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