Version 5.4
Homo sapiens Protein: INPP5A
Summary
InnateDB Protein IDBP-93476.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INPP5A
Protein Name inositol polyphosphate-5-phosphatase, 40kDa
Synonyms 5PTASE;
Species Homo sapiens
Ensembl Protein ENSP00000357583
InnateDB Gene IDBG-93466 (INPP5A)
Protein Structure
UniProt Annotation
Function Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction.
Subcellular Localization Membrane; Lipid-anchor.
Disease Associations
Tissue Specificity Brain; high level in Purkinje cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005515 protein binding
GO:0042731 PH domain binding
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
Biological Process
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0046856 phosphatidylinositol dephosphorylation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000300 Inositol polyphosphate-related phosphatase
IPR005135 Endonuclease/exonuclease/phosphatase
PFAM PF03372
PF14529
PRINTS
PIRSF
SMART SM00128
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14642
PhosphoSite PhosphoSite-Q14642
TrEMBL Q4VAR4
UniProt Splice Variant
Entrez Gene 3632
UniGene Hs.715308
RefSeq NP_005530
HUGO HGNC:6076
OMIM 600106
CCDS CCDS7669
HPRD 02521
IMGT
EMBL AL356603 AL392043 AL451069 BC096280 BC096281 BC117515 CH471211 X77567 Z31695
GenPept AAH96280 AAH96281 AAI17516 CAA54676 CAA83500 CAI14121 CAI39945 CAI40942 EAW61306 EAW61307

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca