InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NKX6-2

Summary

InnateDB Protein

IDBP-93507.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NKX6-2

Protein Name

NK6 homeobox 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357581

InnateDB Gene

IDBG-93505 (NKX6-2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Highest expression in brain. {ECO:0000269PubMed:11210186}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0010454	negative regulation of cell fate commitment
GO:0010455	positive regulation of cell fate commitment
GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
GO:0022010	central nervous system myelination
GO:0030154	cell differentiation
GO:0031018	endocrine pancreas development
GO:0045686	negative regulation of glial cell differentiation
GO:0045687	positive regulation of glial cell differentiation
GO:0048709	oligodendrocyte differentiation
GO:0050885	neuromuscular process controlling balance