InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ME1

Summary

InnateDB Protein

IDBP-93798.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ME1

Protein Name

malic enzyme 1, NADP(+)-dependent, cytosolic

Synonyms

HUMNDME; MES;

Species

Homo sapiens

Ensembl Protein

ENSP00000358719

InnateDB Gene

IDBG-93796 (ME1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:8187880}.

Disease Associations

Tissue Specificity

Expressed in all tissues tested including liver, placenta and white adipose tissue. {ECO:0000269PubMed:7622060, ECO:0000269PubMed:8187880}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004470	malic enzyme activity
GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0004473	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
GO:0005515	protein binding
GO:0008948	oxaloacetate decarboxylase activity
GO:0009055	electron carrier activity
GO:0030145	manganese ion binding
GO:0043531	ADP binding
GO:0046872	metal ion binding
GO:0050661	NADP binding
GO:0051287	NAD binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006108	malate metabolic process
GO:0006741	NADP biosynthetic process
GO:0009725	response to hormone
GO:0009743	response to carbohydrate
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0051262	protein tetramerization
GO:0055114	oxidation-reduction process