InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYB5R4

Summary

InnateDB Protein

IDBP-93912.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYB5R4

Protein Name

cytochrome b5 reductase 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358695

InnateDB Gene

IDBG-93910 (CYB5R4)

Protein Structure

UniProt Annotation

Function

NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

Subcellular Localization

Endoplasmic reticulum {ECO:0000269PubMed:10611283, ECO:0000269PubMed:15131110}. Note=Soluble protein.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10611283}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003958	NADPH-hemoprotein reductase activity
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005515	protein binding
GO:0016174	NAD(P)H oxidase activity
GO:0016491	oxidoreductase activity
GO:0016653	oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0003032	detection of oxygen
GO:0006091	generation of precursor metabolites and energy
GO:0006739	NADP metabolic process
GO:0006801	superoxide metabolic process
GO:0030073	insulin secretion
GO:0042593	glucose homeostasis
GO:0046677	response to antibiotic
GO:0048468	cell development
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001199 Cytochrome b5-like heme/steroid binding domain
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001834 NADH:cytochrome b5 reductase (CBR)
IPR007052 CS domain
IPR008333 Oxidoreductase, FAD-binding domain
IPR008978 HSP20-like chaperone
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00173
PF00175
PF04969
PF00970

PRINTS

PR00363
PR00406

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7L1T6