Version 5.4
Homo sapiens Gene: CYB5R4
Summary
InnateDB Gene IDBG-93910.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYB5R4
Gene Name cytochrome b5 reductase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000065615
Encoded Proteins
IDBP-93912
cytochrome b5 reductase 4
IDBP-93914
cytochrome b5 reductase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:83859643-83967424
Strand Forward strand
Band q14.2
Transcripts
ENST00000369681 ENSP00000358695
ENST00000369679 ENSP00000358693
ENST00000479164
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003958 NADPH-hemoprotein reductase activity
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005515 protein binding
GO:0016174 NAD(P)H oxidase activity
GO:0016491 oxidoreductase activity
GO:0016653 oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0003032 detection of oxygen
GO:0006091 generation of precursor metabolites and energy
GO:0006739 NADP metabolic process
GO:0006801 superoxide metabolic process
GO:0030073 insulin secretion
GO:0042593 glucose homeostasis
GO:0046677 response to antibiotic
GO:0048468 cell development
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032872
View Gene Order
ENSBTAG00000013591
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.5741
RefSeq NM_016230
HUGO
OMIM
CCDS CCDS5000
HPRD 12218
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca