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InnateDB Protein
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IDBP-93914.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CYB5R4
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Protein Name
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cytochrome b5 reductase 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000358693
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InnateDB Gene
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IDBG-93910 (CYB5R4)
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Protein Structure
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| Function |
NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.
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| Subcellular Localization |
Endoplasmic reticulum {ECO:0000269PubMed:10611283, ECO:0000269PubMed:15131110}. Note=Soluble protein.
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| Disease Associations |
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| Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:10611283}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
2
[view]
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| Protein-Protein |
1
[view]
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| Protein-DNA |
1
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
1 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR001199
Cytochrome b5-like heme/steroid binding domain
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| PFAM |
PF00173
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| PRINTS |
PR00363
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q7L1T6
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
51167
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| UniGene |
Hs.5741
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| RefSeq |
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| HUGO |
HGNC:20147
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| OMIM |
608343
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| CCDS |
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| HPRD |
12218
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4