Homo sapiens Protein: ASAP3
Summary
InnateDB Protein IDBP-93932.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASAP3
Protein Name ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000338769
InnateDB Gene IDBG-93928 (ASAP3)
Protein Structure
UniProt Annotation
Function Promotes cell proliferation. {ECO:0000269PubMed:14654939}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:14654939}.
Disease Associations
Tissue Specificity Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes. {ECO:0000269PubMed:14654939}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0016477 cell migration
GO:0032312 regulation of ARF GTPase activity
GO:0032850 positive regulation of ARF GTPase activity
GO:0051492 regulation of stress fiber assembly
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005925 focal adhesion
Protein Structure and Domains
PDB ID
InterPro IPR001164 Arf GTPase activating protein
IPR001849 Pleckstrin homology domain
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF01412
PF00169
PF00023
PF13606
PF11929
PF12796
PRINTS PR00405
PR01415
PIRSF
SMART SM00105
SM00233
SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDY4
PhosphoSite PhosphoSite-Q8TDY4
TrEMBL V9GY49
UniProt Splice Variant
Entrez Gene 55616
UniGene Hs.595123
RefSeq NP_060177
HUGO HGNC:14987
OMIM
CCDS CCDS235
HPRD 11662
IMGT
EMBL AB056749 AK000206 AK092291 AK295100 AL021154 AL357134 BC052305 BC060786 CH471134
GenPept AAH52305 AAH60786 BAA91008 BAB85677 BAG52522 BAG58136 CAI19596 CAI22177 EAW95050 EAW95051 EAW95053