InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NT5E

Summary

InnateDB Protein

IDBP-93983.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NT5E

Protein Name

5'-nucleotidase, ecto (CD73)

Synonyms

CALJA; CD73; E5NT; eN; eNT; NT; NT5; NTE;

Species

Homo sapiens

Ensembl Protein

ENSP00000358665

InnateDB Gene

IDBG-93979 (NT5E)

Protein Structure

UniProt Annotation

Function

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. {ECO:0000269PubMed:21933152}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Calcification of joints and arteries (CALJA) [MIM:211800]: A condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands. {ECO:0000269PubMed:21288095}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0008253	5'-nucleotidase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006195	purine nucleotide catabolic process
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006259	DNA metabolic process
GO:0009166	nucleotide catabolic process
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006179 5\'-Nucleotidase/apyrase
IPR008334 5\'-Nucleotidase, C-terminal
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149
PF02872

PRINTS

PR01607

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21589