Version 5.4
Homo sapiens Protein: LYPLA2
Summary
InnateDB Protein IDBP-94009.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LYPLA2
Protein Name lysophospholipase II
Synonyms APT-2; DJ886K2.4;
Species Homo sapiens
Ensembl Protein ENSP00000363638
InnateDB Gene IDBG-94007 (LYPLA2)
Protein Structure
UniProt Annotation
Function May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43. {ECO:0000250, ECO:0000269PubMed:21152083}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003140 Phospholipase/carboxylesterase/thioesterase
IPR013094 Alpha/beta hydrolase fold-3
IPR029058 Alpha/Beta hydrolase fold
PFAM PF02230
PF07859
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95372
PhosphoSite PhosphoSite-O95372
TrEMBL Q5QPQ0
UniProt Splice Variant
Entrez Gene 11313
UniGene Hs.730360
RefSeq NP_009191
HUGO HGNC:6738
OMIM
CCDS CCDS241
HPRD 07127
IMGT
EMBL AF090423 AF098668 AL031295 BC017034 BC017193
GenPept AAC72844 AAH17034 AAH17193 AAP97210 CAB40158

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca