InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRSF10

Summary

InnateDB Protein

IDBP-94091.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF10

Protein Name

serine/arginine-rich splicing factor 10

Synonyms

FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13; SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000363576

InnateDB Gene

IDBG-94079 (SRSF10)

Protein Structure

UniProt Annotation

Function

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. {ECO:0000269PubMed:11684676, ECO:0000269PubMed:12419250, ECO:0000269PubMed:14765198}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:11684676}. Cytoplasm {ECO:0000269PubMed:11684676}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:11684676, ECO:0000269PubMed:11891055}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	63 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0050733	RS domain binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000244	spliceosomal tri-snRNP complex assembly
GO:0000375	RNA splicing, via transesterification reactions
GO:0000398	mRNA splicing, via spliceosome
GO:0006355	regulation of transcription, DNA-templated
GO:0006376	mRNA splice site selection
GO:0006406	mRNA export from nucleus
GO:0016482	cytoplasmic transport
GO:0048025	negative regulation of mRNA splicing, via spliceosome