InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRHL3

Summary

InnateDB Protein

IDBP-94179.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRHL3

Protein Name

grainyhead-like 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000288955

InnateDB Gene

IDBG-94173 (GRHL3)

Protein Structure

UniProt Annotation

Function

May function as a transcription factor. {ECO:0000269PubMed:12549979}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in brain, colon, pancreas, placenta and kidney. Isoform 1 is expressed in lung and tonsil. Isoform 2 is prostate-specific. {ECO:0000269PubMed:12549979}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0001736	establishment of planar polarity
GO:0006366	transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0007398	ectoderm development
GO:0007417	central nervous system development
GO:0008544	epidermis development
GO:0010628	positive regulation of gene expression
GO:0032321	positive regulation of Rho GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0042060	wound healing
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0061029	eyelid development in camera-type eye
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure