Version 5.4
Homo sapiens Gene: GRHL3
Summary
InnateDB Gene IDBG-94173.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRHL3
Gene Name grainyhead-like 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158055
Encoded Proteins
IDBP-94175
grainyhead-like 3 (Drosophila)
IDBP-94179
grainyhead-like 3 (Drosophila)
IDBP-94181
grainyhead-like 3 (Drosophila)
IDBP-94185
grainyhead-like 3 (Drosophila)
IDBP-587082
grainyhead-like 3 (Drosophila)
IDBP-592700
grainyhead-like 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the grainyhead family of transcription factors. The encoded protein may function as a transcription factor during development, and has been shown to stimulate migration of endothelial cells. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:24319322-24364482
Strand Forward strand
Band p36.11
Transcripts
ENST00000361548 ENSP00000354943
ENST00000350501 ENSP00000288955
ENST00000356046 ENSP00000348333
ENST00000236255 ENSP00000236255
ENST00000461318
ENST00000530984
ENST00000524724 ENSP00000431290
ENST00000528064 ENSP00000435130
ENST00000528181
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0001736 establishment of planar polarity
GO:0006366 transcription from RNA polymerase II promoter
GO:0007389 pattern specification process
GO:0007398 ectoderm development
GO:0007417 central nervous system development
GO:0008544 epidermis development
GO:0010628 positive regulation of gene expression
GO:0032321 positive regulation of Rho GTPase activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0042060 wound healing
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0061029 eyelid development in camera-type eye
GO:0090103 cochlea morphogenesis
GO:0090179 planar cell polarity pathway involved in neural tube closure
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037188
View Gene Order
ENSBTAG00000019791
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.657920
RefSeq NM_001195010 NM_021180 NM_198173 NM_198174
HUGO
OMIM
CCDS CCDS251 CCDS252 CCDS44088 CCDS53284
HPRD 12210
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca