InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRRM1

Summary

InnateDB Protein

IDBP-94242.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRRM1

Protein Name

serine/arginine repetitive matrix 1

Synonyms

160-KD; POP101; SRM160;

Species

Homo sapiens

Ensembl Protein

ENSP00000326261

InnateDB Gene

IDBG-94238 (SRRM1)

Protein Structure

UniProt Annotation

Function

Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269PubMed:10339552, ECO:0000269PubMed:10668804, ECO:0000269PubMed:11739730, ECO:0000269PubMed:12600940, ECO:0000269PubMed:12944400, ECO:0000269PubMed:9531537}.

Subcellular Localization

Nucleus matrix. Nucleus speckle.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 142 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	142 [view]
Protein-Protein	142 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005829	cytosol
GO:0016363	nuclear matrix
GO:0016607	nuclear speck
GO:0071013	catalytic step 2 spliceosome