InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNGTT

Summary

InnateDB Protein

IDBP-94247.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNGTT

Protein Name

RNA guanylyltransferase and 5'-phosphatase

Synonyms

CAP1A; hCAP; HCE; HCE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000358497

InnateDB Gene

IDBG-94245 (RNGTT)

Protein Structure

UniProt Annotation

Function

Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. {ECO:0000269PubMed:21636784, ECO:0000269PubMed:9473487, ECO:0000269PubMed:9512541}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004484	mRNA guanylyltransferase activity
GO:0004651	polynucleotide 5'-phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005525	GTP binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0008192	RNA guanylyltransferase activity
GO:0016791	phosphatase activity
GO:0050355	triphosphatase activity

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0006470	protein dephosphorylation
GO:0010467	gene expression
GO:0016032	viral process
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0098507	polynucleotide 5' dephosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001339 mRNA capping enzyme
IPR012340 Nucleic acid-binding, OB-fold
IPR013846 mRNA capping enzyme, C-terminal
IPR017074 mRNA capping enzyme, bifunctional
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782
PF01331
PF03919

PRINTS

PR00700

PIRSF

PIRSF036958

SMART

SM00194

TIGRFAMs

Post-translational Modifications

Modification

Cross-References