InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GJA10

Summary

InnateDB Protein

IDBP-94352.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GJA10

Protein Name

gap junction protein, alpha 10, 62kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358358

InnateDB Gene

IDBG-94350 (GJA10)

Protein Structure

UniProt Annotation

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle and heart. {ECO:0000269PubMed:12881038}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005243	gap junction channel activity

Biological Process

GO:0007268	synaptic transmission
GO:0007276	gamete generation
GO:0007416	synapse assembly
GO:0009416	response to light stimulus
GO:0050908	detection of light stimulus involved in visual perception
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0005922	connexon complex
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000500 Connexin
IPR013092 Connexin, N-terminal
IPR019570 Gap junction protein, cysteine-rich domain
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00029
PF10582

PRINTS

PR00206

PIRSF

SMART

SM00037
SM01089

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt