InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAN1C1

Summary

InnateDB Protein

IDBP-94367.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAN1C1

Protein Name

mannosidase, alpha, class 1C, member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000363452

InnateDB Gene

IDBG-94363 (MAN1C1)

Protein Structure

UniProt Annotation

Function

Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.

Subcellular Localization

Golgi apparatus membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509	calcium ion binding

Biological Process

GO:0006487	protein N-linked glycosylation
GO:0008152	metabolic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process