InnateDB Protein
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IDBP-94411.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EPHA7
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Protein Name
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EPH receptor A7
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Synonyms
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EHK-3; EHK3; EK11; HEK11;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000358303
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InnateDB Gene
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IDBG-94407 (EPHA7)
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Protein Structure
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Function |
Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. {ECO:0000269PubMed:17726105}.
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Subcellular Localization |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Widely expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
17
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001090
Ephrin receptor ligand binding domain
IPR008979
Galactose-binding domain-like
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PFAM |
PF01404
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PRINTS |
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PIRSF |
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SMART |
SM00615
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TIGRFAMs |
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Modification |
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SwissProt |
Q15375
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PhosphoSite |
PhosphoSite-Q15375
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
2045
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UniGene |
Hs.73962
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RefSeq |
NP_001275559
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HUGO |
HGNC:3390
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OMIM |
602190
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CCDS |
CCDS75494
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HPRD |
03721
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IMGT |
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EMBL |
AB209269
AK313529
AL121966
AL354857
AL591036
BC027940
BC126125
BC126151
BC143857
BC143858
CH471051
L36642
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GenPept |
AAA74243
AAH27940
AAI26126
AAI26152
AAI43858
AAI43859
BAD92506
BAG36308
CAC19520
CAH72780
CAH73650
CAI19722
EAW48518
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