InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PAFAH2

Summary

InnateDB Protein

IDBP-94446.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAFAH2

Protein Name

platelet-activating factor acetylhydrolase 2, 40kDa

Synonyms

HSD-PLA2;

Species

Homo sapiens

Ensembl Protein

ENSP00000363400

InnateDB Gene

IDBG-94440 (PAFAH2)

Protein Structure

UniProt Annotation

Function

Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Broadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0005543	phospholipid binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006629	lipid metabolic process
GO:0016042	lipid catabolic process
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR005065 Platelet-activating factor acetylhydrolase
IPR016715 Platelet-activating factor acetylhydrolase, eucaryote
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00326
PF03403

PRINTS

PIRSF

PIRSF018169

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99487