Version 5.4
Homo sapiens Gene: PAFAH2
Summary
InnateDB Gene IDBG-94440.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAFAH2
Gene Name platelet-activating factor acetylhydrolase 2, 40kDa
Synonyms HSD-PLA2
Species Homo sapiens
Ensembl Gene ENSG00000158006
Encoded Proteins
IDBP-94444
platelet-activating factor acetylhydrolase 2, 40kDa
IDBP-94446
platelet-activating factor acetylhydrolase 2, 40kDa
IDBP-376142
platelet-activating factor acetylhydrolase 2, 40kDa
IDBP-376146
platelet-activating factor acetylhydrolase 2, 40kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:25959767-25998157
Strand Reverse strand
Band p36.11
Transcripts
ENST00000374284 ENSP00000363402
ENST00000374282 ENSP00000363400
ENST00000439092 ENSP00000408313
ENST00000441420 ENSP00000411011
ENST00000493892
ENST00000464540
ENST00000476611
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0005543 phospholipid binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006629 lipid metabolic process
GO:0016042 lipid catabolic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037366
View Gene Order
ENSBTAG00000005105
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00565
Ether lipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.477083
RefSeq NM_000437 XM_006710668 XM_006710669 XM_006710670
HUGO
OMIM
CCDS CCDS270
HPRD 03824
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca