InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FUT9

Summary

InnateDB Protein

IDBP-94449.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FUT9

Protein Name

fucosyltransferase 9 (alpha (1,3) fucosyltransferase)

Synonyms

Fuc-TIX;

Species

Homo sapiens

Ensembl Protein

ENSP00000302599

InnateDB Gene

IDBG-94447 (FUT9)

Protein Structure

UniProt Annotation

Function

Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides. {ECO:0000269PubMed:10386598}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.

Disease Associations

Tissue Specificity

Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus. {ECO:0000269PubMed:10386598}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008417	fucosyltransferase activity
GO:0046920	alpha-(1->3)-fucosyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006486	protein glycosylation
GO:0007399	nervous system development
GO:0036065	fucosylation
GO:0042355	L-fucose catabolic process