InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASCC3

Summary

InnateDB Protein

IDBP-94668.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASCC3

Protein Name

activating signal cointegrator 1 complex subunit 3

Synonyms

ASC1p200; HELIC1; RNAH;

Species

Homo sapiens

Ensembl Protein

ENSP00000358159

InnateDB Gene

IDBG-94666 (ASCC3)

Protein Structure

UniProt Annotation

Function

3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. {ECO:0000269PubMed:22055184}.

Subcellular Localization

Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0043140	ATP-dependent 3'-5' DNA helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006307	DNA dealkylation involved in DNA repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008283	cell proliferation
GO:0032508	DNA duplex unwinding
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR003593 AAA+ ATPase domain
IPR004179 Sec63 domain
IPR006935 Helicase/UvrB domain
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF02889
PF04851
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00382
SM00611
SM00973
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8N3C0