Version 5.4
Homo sapiens Gene: ASCC3
Summary
InnateDB Gene IDBG-94666.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASCC3
Gene Name activating signal cointegrator 1 complex subunit 3
Synonyms ASC1p200; HELIC1; RNAH
Species Homo sapiens
Ensembl Gene ENSG00000112249
Encoded Proteins
IDBP-94668
activating signal cointegrator 1 complex subunit 3
IDBP-94670
activating signal cointegrator 1 complex subunit 3
IDBP-94674
activating signal cointegrator 1 complex subunit 3
IDBP-94676
activating signal cointegrator 1 complex subunit 3
IDBP-474292
activating signal cointegrator 1 complex subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23781071
ASCC3 inhibits IFN-signalling to dampen antiviral innate immunity.
Entrez Gene
Summary This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:100508194-100881372
Strand Reverse strand
Band q16.3
Transcripts
ENST00000369162 ENSP00000358159
ENST00000324696 ENSP00000320252
ENST00000369143 ENSP00000358139
ENST00000324723 ENSP00000320777
ENST00000518006
ENST00000522650 ENSP00000430769
ENST00000468245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0043140 ATP-dependent 3'-5' DNA helicase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006307 DNA dealkylation involved in DNA repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008283 cell proliferation
GO:0032508 DNA duplex unwinding
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038774
View Gene Order
ENSBTAG00000020482
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.486031 Hs.602643 Hs.733060
RefSeq NM_001284271 NM_006828 NM_022091 XM_006715322
HUGO
OMIM
CCDS CCDS5046 CCDS5047 CCDS75497
HPRD 16805
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca