Homo sapiens Protein: RPS6KA1
Summary
InnateDB Protein IDBP-94684.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPS6KA1
Protein Name ribosomal protein S6 kinase, 90kDa, polypeptide 1
Synonyms HU-1; MAPKAPK1A; RSK; RSK1;
Species Homo sapiens
Ensembl Protein ENSP00000363281
InnateDB Gene IDBG-94680 (RPS6KA1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 85 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 85 [view]
Protein-Protein 85 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006468 protein phosphorylation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR016239 Ribosomal protein S6 kinase II
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PF06293
PF00433
PRINTS PR00109
PIRSF PIRSF000606
SMART SM00133
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PMM7
UniProt Splice Variant
Entrez Gene 6195
UniGene Hs.149957
RefSeq
HUGO HGNC:10430
OMIM 601684
CCDS
HPRD 03402
IMGT
EMBL AL627313
GenPept