Version 5.4
Homo sapiens Protein: NUDC
Summary
InnateDB Protein IDBP-94767.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUDC
Protein Name nuclear distribution gene C homolog (A. nidulans)
Synonyms HNUDC; MNUDC; NPD011;
Species Homo sapiens
Ensembl Protein ENSP00000319664
InnateDB Gene IDBG-94765 (NUDC)
Protein Structure
UniProt Annotation
Function Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation. {ECO:0000250, ECO:0000269PubMed:12679384, ECO:0000269PubMed:12852857}.
Subcellular Localization Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern.
Disease Associations
Tissue Specificity Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart. {ECO:0000269PubMed:10210332, ECO:0000269PubMed:10453739}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 127 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 127 [view]
Protein-Protein 127 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
Protein Structure and Domains
PDB ID
InterPro IPR007052 CS domain
IPR008978 HSP20-like chaperone
PFAM PF04969
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y266
PhosphoSite PhosphoSite-Q9Y266
TrEMBL
UniProt Splice Variant
Entrez Gene 10726
UniGene
RefSeq NP_006591
HUGO HGNC:8045
OMIM 610325
CCDS CCDS292
HPRD 10122
IMGT
EMBL AB019408 AF086922 AF100760 AF125465 AF130736 AL136725 AL356390 BC002399 BC003132 BC006147 BC007280 BC015153 BC021139
GenPept AAD30517 AAD39921 AAD43024 AAH02399 AAH03132 AAH06147 AAH07280 AAH15153 AAH21139 AAP97152 BAA76628 CAB66659 CAI13560 CAI13561 CAI13563

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca