InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BVES

Summary

InnateDB Protein

IDBP-94778.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BVES

Protein Name

blood vessel epicardial substance

Synonyms

HBVES; POP1; POPDC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000313172

InnateDB Gene

IDBG-94774 (BVES)

Protein Structure

UniProt Annotation

Function

Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3- mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. {ECO:0000269PubMed:16188940}.

Subcellular Localization

Lateral cell membrane {ECO:0000269PubMed:16188940}. Cell junction, tight junction {ECO:0000269PubMed:16188940}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle. {ECO:0000269PubMed:10441744, ECO:0000269PubMed:10882522, ECO:0000269PubMed:16188940}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0030552	cAMP binding

Biological Process

GO:0001921	positive regulation of receptor recycling
GO:0002027	regulation of heart rate
GO:0002244	hematopoietic progenitor cell differentiation
GO:0007517	muscle organ development
GO:0008360	regulation of cell shape
GO:0016192	vesicle-mediated transport
GO:0032314	regulation of Rac GTPase activity
GO:0034446	substrate adhesion-dependent cell spreading
GO:0040017	positive regulation of locomotion
GO:0042391	regulation of membrane potential
GO:0043088	regulation of Cdc42 GTPase activity
GO:0060931	sinoatrial node cell development
GO:0090136	epithelial cell-cell adhesion