InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRDM1

Summary

InnateDB Protein

IDBP-94829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRDM1

Protein Name

PR domain containing 1, with ZNF domain

Synonyms

BLIMP1; PRDI-BF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000358092

InnateDB Gene

IDBG-94825 (PRDM1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:21421998}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	21 [view]
Protein-DNA	37 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001892	embryonic placenta development
GO:0001893	maternal placenta development
GO:0006351	transcription, DNA-templated
GO:0007281	germ cell development
GO:0009791	post-embryonic development
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0030889	negative regulation of B cell proliferation
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032259	methylation
GO:0042462	eye photoreceptor cell development
GO:0045165	cell fate commitment
GO:0045579	positive regulation of B cell differentiation
GO:0060576	intestinal epithelial cell development
GO:0060707	trophoblast giant cell differentiation