Version 5.4
Homo sapiens Protein: PRDM1
Summary
InnateDB Protein IDBP-94833.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRDM1
Protein Name PR domain containing 1, with ZNF domain
Synonyms BLIMP1; PRDI-BF1;
Species Homo sapiens
Ensembl Protein ENSP00000358085
InnateDB Gene IDBG-94825 (PRDM1)
Protein Structure
UniProt Annotation
Function Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:21421998}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 21 [view]
Protein-DNA 37 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0032259 methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001214 SET domain
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
IPR016608 PR-domain zinc finger protein PRDM1
PFAM PF00856
PF00096
PRINTS
PIRSF PIRSF013212
SMART SM00317
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75626
PhosphoSite PhosphoSite-O75626
TrEMBL B4DW27
UniProt Splice Variant
Entrez Gene 639
UniGene Hs.436023
RefSeq NP_878911
HUGO HGNC:9346
OMIM 603423
CCDS CCDS34505
HPRD 04572
IMGT
EMBL AF084199 AK301341 AL022067 AL358952 AY198414 AY198415 BC103832 BC103833 BC103834 CH471051
GenPept AAC33300 AAI03833 AAI03834 AAI03835 AAO45623 AAO45624 BAG62889 CAI42295 CAQ52574 CAQ52608 EAW48419 EAW48421 EAW48422

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca