InnateDB Protein
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IDBP-94884.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FCN3
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Protein Name
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ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
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Synonyms
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FCNH; HAKA1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000347077
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InnateDB Gene
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IDBG-94882 (FCN3)
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Protein Structure
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Function |
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. {ECO:0000269PubMed:11907111}.
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Subcellular Localization |
Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct.
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Disease Associations |
Ficolin 3 deficiency (FCN3D) [MIM:613860]: A disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. {ECO:0000269PubMed:19535802}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells. {ECO:0000269PubMed:10330454}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002181
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR008160
Collagen triple helix repeat
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PFAM |
PF00147
PF01391
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PRINTS |
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PIRSF |
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SMART |
SM00186
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TIGRFAMs |
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Modification |
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SwissProt |
O75636
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PhosphoSite |
PhosphoSite-O75636
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TrEMBL |
Q6UY50
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UniProt Splice Variant |
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Entrez Gene |
8547
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UniGene |
Hs.627093
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RefSeq |
NP_775628
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HUGO |
HGNC:3625
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OMIM |
604973
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CCDS |
CCDS301
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HPRD |
05399
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IMGT |
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EMBL |
AK075140
AY358081
AY358283
AY756173
BC020731
CH471059
CR456808
D88587
FO393419
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GenPept |
AAH20731
AAQ88448
AAQ88650
AAU85296
BAA32277
BAC11429
CAG33089
EAX07757
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