Version 5.4
Homo sapiens Protein: FCN3
Summary
InnateDB Protein IDBP-94886.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCN3
Protein Name ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
Synonyms FCNH; HAKA1;
Species Homo sapiens
Ensembl Protein ENSP00000270879
InnateDB Gene IDBG-94882 (FCN3)
Protein Structure
UniProt Annotation
Function May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. {ECO:0000269PubMed:11907111}.
Subcellular Localization Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct.
Disease Associations Ficolin 3 deficiency (FCN3D) [MIM:613860]: A disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. {ECO:0000269PubMed:19535802}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells. {ECO:0000269PubMed:10330454}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0001867 complement activation, lectin pathway
GO:0006956 complement activation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR008160 Collagen triple helix repeat
PFAM PF00147
PF01391
PRINTS
PIRSF
SMART SM00186
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75636
PhosphoSite PhosphoSite-O75636
TrEMBL
UniProt Splice Variant
Entrez Gene 8547
UniGene Hs.627093
RefSeq NP_003656
HUGO HGNC:3625
OMIM 604973
CCDS CCDS300
HPRD 05399
IMGT
EMBL AK075140 AY756173 BC020731 CR456808 D88587 FO393419
GenPept AAH20731 AAU85296 BAA32277 BAC11429 CAG33089

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca