Version 5.4
Homo sapiens Protein: SOBP
Summary
InnateDB Protein IDBP-94952.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOBP
Protein Name sine oculis binding protein homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000318900
InnateDB Gene IDBG-94950 (SOBP)
Protein Structure
UniProt Annotation
Function Implicated in development of the cochlea. {ECO:0000250UniProtKB:Q0P5V2}.
Subcellular Localization
Disease Associations Mental retardation, anterior maxillary protrusion, and strabismus (MRAMS) [MIM:613671]: A syndrome characterized by severe mental retardation, strabismus and dysmorphic features such as anterior maxillary protrusion with vertical maxillary excess, open bite and prominent crowded teeth. Some patients may lack dysmorphic features and manifest temporal lobe epilepsy and psychosis. Esotropia and amblyopia are present in some individuals. {ECO:0000269PubMed:21035105}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0032184 SUMO polymer binding
GO:0046872 metal ion binding
Biological Process
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0042472 inner ear morphogenesis
Cellular Component
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A7XYQ1
PhosphoSite PhosphoSite-A7XYQ1
TrEMBL
UniProt Splice Variant
Entrez Gene 55084
UniGene Hs.706049
RefSeq NP_060483
HUGO HGNC:29256
OMIM 613667
CCDS CCDS43488
HPRD 07650
IMGT
EMBL AK090879 AL096816 AL121957 AL671934 BC091526 DQ507800
GenPept AAH91526 ABF72848 BAC03537 CAQ08124 CAQ10205 CAQ10380

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca